| Week |
Date |
Topic |
Assignment Due |
| 1 |
13 Jan
Lecture 1
Audio recording of Lecture 1 |
Course Introduction
Chapter 1: The Foundations of Biochemistry
1.1: Cellular Foundations
1.2: Chemical Foundations
1.3: Physical Foundations
1.4: Genetic Foundations
1.5: Evolutionary Foundations |
Show up to class ready to get to work! |
15 Jan |
No Class Meeting Today! |
17 Jan
Lecture 2
Audio recording of Lecture 2 |
Chapter 2: Water
2.1: Weak Interactions in Aqueous SYstems
2.2: Ionization of Water, Weak Acids and Weak Bases
2.3: Buffering against pH Changes in Biological Systems
2.4: Water as a Reactant
2.5: The Fitness of the Aqueous Environment for Living Organisms |
HW1: Chapter 1 Problems 2, 7, 9, 16 Crossword 1 |
| 2 |
20 Jan
|
Martin Luther King, Jr. Holiday
No Scheduled Meeting |
22 Jan
Lecture 3 |
Chapter 3: Amino Acids, Peptides and Proteins
3.1: Amino Acids
3.2: Peptides and Proteins |
HW2 Syllabus and Website homework, Chapter 2 Problems 1, 2, 4, 9, 16, 20, 27, 28, 31, 35, Crossword 2 |
24 Jan
Audio recording of Lecture 3 Part 2 |
3.3: Working with Proteins
3.4: The Structure of Proteins: Primary Structure |
|
| 3 |
27 Jan
Lecture 4
Audio recording of Lecture 4 Part 1
|
Chapter 4: The 3D Structure of Proteins
4.1: Overview of Protein Structure
4.2: Protein Secondary Structure |
HW3 Chapter 3 Problems 2, 7, 8, 9, 11, 15, 18, 21, 22, Crossword 3 |
29 Jan
Audio recording of Lecture 4 Part 2 |
Chapter 4: The 3D Structure of Proteins
4.3: Protein Tertiary and Quaternary Structures
4.4: Protein Denaturation and Folding |
|
31 Jan
Lecture 3a
Lecture 4a |
Using NCBI/Entrez
An introduction to the PDB and PDB Files |
HW4 Chapter 4 Problems 1, 4, 7, 10, 15, 16, Crossword 4 |
4 |
3 Feb
Lecture 5 |
Chapter 5: Protein Function
5.1: Reversible Binding of a Protein to a Ligand: Oxygen-binding Proteins |
|
5 Feb
Lecture 6 |
Chapter 6: Enzymes
6.1: An Introduction to Enzymes
6.2: How Enzymes Work
6.3: Enzyme Kinetics as an Approach to Understanding Mechanism |
HW5 Chapter 5 Problems1, 2, 8, 15 |
7 Feb
|
|
PDB Assignment Due |
| 5 |
10 Feb
Lecture 7 |
Chapter 6: Enzymes
6.4: Examples of Enzymatic Mechanisms |
|
12 Feb
|
|
Chimera Assignment Due |
14 Feb
Lecture 8 |
6.5: Regulation of Enzymatic Activty
|
HW6 Chapter 6: 4, 5, 6, 8, 9, 10, 11, 16,19, 21, 22, 23, Crossword 6 |
| 6 |
17 Feb |
Test 1 |
19 Feb
Lecture 9 |
Chapter 7: Carbohydrates and Glycobiology
7.1: Monosaccharides and Disaccharides
7.2: Polysaccharides
7.3: Glycoconjugates: Proteoglycans, Glycoproteins and Glycosphingolipids
7.4: Carbohydrates as Informational Molecules: The Sugar Code |
|
21 Feb |
|
|
| 7 |
24 Feb
Lecture 11 |
Chapter 8: Nucleotides and Nucleic Acids
8.1: Some Basics
8.2: Mucleic Acid Structure
8.3: Nucleic Acid Chemistry
8.4: Other Functions of Nucleotides
|
HW 7: Chapter 7 Problems 2, 7, 15, 17, 20, 27, Crossword 7 |
26 Feb
Lecture 12
|
Chapter 10: Lipids
10.1: Storage Lipids
10.2: Structural Lipids in Membranes
10.3: Lipids as Signals, Cofactors and Pigments |
HW8: Chapter 8 Problems 1, 2, 10, 11, 14, 18, Crossword 8 |
28 Feb
Lecture 13
|
Chapter 11: Biological Membranes
11.1: The Compositon and Architecture of Membranes
11.2: Membrane Dynamics
11.3: Solute Transport Across Membranes |
HW9: Chapter 10 Problems 2, 9, 12, 14, Crossword 10 |
| 8 |
3 Mar
|
|
|
5 Mar
Lecture 14
|
Chapter 12: Biosignaling
12.1: General Features of Signal Transduction
12.2: G-Protein Coupled Receptors and Second Messengers |
HW10: Chapter 11 Problems 4, 6, 24, 25, Crossword 11 |
7 Mar
Lecture 15
|
Chapter 12: Biosignaling
12.3: Receptor Tyrosine Kinases
12.11: Regulation of Cell Cycle by Protein Kinases
Movie of INSR Activation |
|
| 9 |
10 Mar |
Review for Exam |
HW11: Chapter 12 Problems 3, 10, 13 |
12 Mar |
Review for Exam |
|
| 14 Mar |
Test 2 |
| 10 |
17 Mar - 21 Mar |
Spring Break |
| 11 |
24 Mar
Lecture 17 |
Chapter 24: Genes and Chromosomes
Supplemental Article:
John Nitiss. (2009). Targeting DNA topoisomerase II in cancer chemotherapy. Nature Cancer Reviews 9: 338–350. |
|
26 Mar
Lecture 18 |
Chapter 25: DNA Metabolism
25.1: DNA Replication |
|
| 28 Mar |
|
HW12: Chapter 24 Problems 4, 6, 14, 15, Crossword 24 |
12 |
31 Mar
Lecture 19 |
Chapter 26: RNA Metabolism
26.1: DNA-dependent Synthesis of RNA |
|
| 2 Apr |
|
|
4 Apr
|
Biological Redox Reactions |
HW13: Chapter 25 Problems 1, 8, 9, 10, 11 |
13 |
7 Apr
Lecture 20 |
Chapter 27: Protein Metabolism
27.1: The Genetic Code
27.2: Protein Synthesis |
|
9 Apr
|
Test 3 Review |
|
| 11 Apr |
Test 3 Review |
HW14: Chapter 26 Problems 5, 11, 12, Crossword 26 |
14 |
14 Apr |
Test 3 |
| 16 Apr |
Presentation Review |
| 18 Apr |
Presentation Review |
15 |
21 Apr |
Rosa Razo
Nick Miller
Derion Reid
Charles Nelson |
| 23 Apr |
Montana Houssard
Lucas Boncorddo
Grace Jones
Jamie Murakami |
| 25 Apr |
Lukas Ballard
Sarah Wicks
Stephanie Henry
Matthew Raad |
| 16 |
Monday, 28 Apr @ 9:00AM |
Final Paper Due in Dropbox Folder |
| |
| Final Exam: Tuesday, 6 May at 11:30 AM in Sims 113C |