• Electronegativity & Coulomb’s Law
• Intermolecular Forces
• Solubility
• Hydrophobic/Hydrophilic Substances
• Vapor Pressure
• Kinetic Energy Molecular Distribution

• Kotz: 9.8-9.9,13.1-13.5, 14.2,14.5
• Biochem: 2.1-2.2
• CHEMGUIDE Bonding Menu
• Log P and pKa

• Molecular Geometry
• Hybridization
• Double Bond Geometry
• Aromatic Electronic Structure
• Fatty Acids, Amino Acids, Alkaloids, Glycerol

• Kotz: 10.2,11.3-11.4,pp 531-532

• Reaction between Alcohols and Carboxylic Acids
• Triglyceride Formation
• Peptide Formation and Hydrolysis
• Polyphosphate Formation

• Phospholipid Formation and Structure
• Surfactants and Soaps
• Membrane Structure and Properties

• "The Components and Properties of Cell Membranes"
• UCSF Membrane Tutorial
• Biochem: 8.1-8.5
• Phospholipids
• Cell Membranes

• Types of Side Chains
• Henderson-Hasselbalch Equation
• Charge and pH
• Isoelectric Points

• Biochem: 2.4,3.1-3.3

• Condensation and Hydrolysis 
• Peptide Bond Geometry and Resonance
• Protein Primary Structure and Disulfide Bonds
• Secondary Structure - Alpha Helices, Beta Sheets
• Key Interactions for Protein Folding, Prions

• "Protein Structure and ATP"
• Biochem: 3.4-3.5; 4.1-4.6
• Proteins

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• Chemical Reaction Requirements
• Arrhenius Model
• Reaction Rates and Rate Law 
• Arrhenius Equation
• Experimental Determination of Reaction Order 
• Rate Constants and Activation Energy
• Arrhenius Plots

• Kotz: 15.5
• Biochem: 6.1-6.5
• Kotz 15.3

• Enzyme Mechanism of Action
• Enzyme Inhibition
• Enzyme-Substrate Interactions
• Michaelis-Menton Kinetics
• Lineweaver-Burke Plots

• Biochem: 6.6-6.7
• Enzymes
• Enzyme Kinetics
• Enzyme Kinetics Tutorial

• Noncovalent Interactions
• Agonists and Antagonists
• Dose-Response Curves
• Overview of Receptor Types

• "Introduction to Pharmacology" 
• "Quantification of Pharmacodynamic Effects" 

• Routes of Administration
• Membrane Solubility
• Effects of pH 
• Half-lives and Removal Rates

• "Introduction to Pharmacology"
• "Pharmacokinetics I"
• "Lipid Diffusion" from "Diffusion and Transport across Cell Membranes"
• "Pharmacokinetics II"

• Arachidonic Acid Initiated Inflammation
• Mechanism of Action for COX Inhibitors
• Structure of Nonspecific COX Inhibitors

• "Cyclooxygenase" from "Protein Function"
• Biochem: 8.8
• UM NSAID PowerPoint Lecture

• Rationale for COX-2 Development
• Molecular Design
• Mechanism of Action
• Therapeutic Utility and Side Effects

• Biochem: 8.8
• "Cyclooxygenase" from "Protein Function"
• "Cox in a Crystal Ball" JCI article
• David Graham's COX-2 FDA Memo

• DNA Structure
• Codons and RNA
• Ligands, Metal Ions, and Complexes

• Kotz: 22.3-22.6
• Biochem: 9.1-9.3, 12.2

• Steroid Structures and Properties
• Roles as Hormones

• Biochem: pp189-191, 24.3
• Steroid Handout

• Steroidal Anti-Inflammatory Mechanism of Action
• Zinc Finger Steroid Receptors

• "Nuclear Receptors" from "Protein Function"
• Biochem: pp189-191, 24.3

• Neurotransmission Handout 

• Biochem: 1.9-1.12; 15.1-15.6;20.1-20.2
• Kotz: 19.4-19.7; 20.4-20.6

• Biochem: 1.9-1.12; 15.1-15.6;20.1-20.2
• Kotz: 19.4-19.7; 20.4-20.6

• Biochem: 8.6; 20.1-20.2
• "Active Carriers" from "Diffusion and Transport across Cell Membranes"

• "Ion Channels" from "Diffusion and Transport across Cell Membranes"

• Neurotransmission Handout

• Neurotransmission Handout

• Anesthetics and Opioid Analgesics Handout

• Anesthetics and Opioid Analgesics Handout

• Neurotransmission Handout