Lesson 12: COX-2 Inhibitors

• Understand key differences between COX-1 and COX-2 enzymes, their physiological roles, and their respective inhibitors
• Clearly describe the rationale for the development of COX-2 inhibitors
• Explain the structure differences between nonspecific COX inhibitors and COX-2 specific inhibitors; relate these differences to active site geometries of thee two enzymes
• Use COX-1 and COX-2 IC50 values for various substances to evaluate their respective potential for therapeutic development