General Chemistry II Spring 2007 Course Syllabus

Date
 (Competencies)

Topic 

Readings

1/9
Competencies Lsn 1

Intro to Drug Targets and Interactions I
(Intermolecular Forces, Molecular Structure, Lewis Structures)

  • Intermolecular Forces
  • Molecular Geometry
  • Hybridization, Double Bond Geometry
  • Aromatic Electronic Structure
  • Vapor Pressure
  • Kinetic Energy Molecular Distribution

1/11
Competencies Lsn 2

PS1 Due

Intro to Drug Targets and Interactions II
(Solubility, log P Calculations, Phospholipids, Membranes)

  • Solubility and Thermodynamics
  • Log P (Octanol-Water Partition Coefficient)
  • Surfactants and Soaps
  • Phospholipid Structure & Components
  • Membrane Structure and Properties

1/16
Competencies Lsn 3

PS2 Due

Intro to Drug Targets and Interactions III
(Condensation and Hydrolysis Reactions)

·  Alcohols and Carboxylic Acids

·  Triglyceride Formation

·  Peptide Formation and Hydrolysis

·  Polyphosphate Formation

  • Medicinal Chemistry: Chapter 2

1/18
Competencies Lsn 4

PS3 Due

Proteins as Drug Targets I
(Amino Acids, Acid-Base Properties, Henderson-Hasselbalch)

  • Types of Side Chains
  • Henderson-Hasselbalch Equation
  • Charge and pH
  • Isoelectric Points
  • Medicinal Chemistry: Chapter 3

1/23
Competencies Lsn 5

PS4 Due

Proteins as Drug Targets II
(Protein structure)

  • Peptide Bond Geometry and Resonance
  • Protein Primary Structure and Disulfide Bonds
  • Secondary Structure - Alpha Helices, Beta Sheets
  • Key Interactions for Protein Folding, Prions
  • Post-Translational Protein Modications
  • Medicinal Chemistry: Chapter 3
  • "Protein Structure and ATP"
  • Proteins

1/25
Competencies Lsn 6

Enzymes as Drug Targets I
(Reaction kinetics, equilibrium constants, binding interactions)

  • Arrhenius Reaction Model
  • Transition states, Activation Energy, Catalysis
  • Enzyme-Substrate Interactions, Active Sites
  • Enzyme Inhibition

1/30

Competencies Lsn 7

Enzymes as Drug Targets II
(Enzyme Kinetics)

  • Michaelis-Menton equation
  • Michaelis Constant, Dissociation Constant
  • Lineweaver-Burk Plots
  • Turnover Number, Vmax
  • Medicinal Chemistry: Chapter 4

2/6

Competencies Lsn 7

Enzymes as Drug Targets III
(Enzyme Kinetics)

  • Michaelis-Menton equation
  • Michaelis Constant, Dissociation Constant
  • Lineweaver-Burk Plots
  • Turnover Number, Vmax

 

 

2/8
Competencies Lsn 8

Receptors as Drug Targets I

  • Neurotransmittors and Hormones
  • Receptors: Ion Channels & Membrane Receptors
  • Receptor-Ligand Interactions
  • Agonists and Antagonists
  • Sensitization, Tolerance, and Dependence
  • Medicinal Chemistry: Chapter 5

 

2/13
Competencies Lsn 9

Receptors as Drug Targets II

  • Affinity, Efficacy, & Potency
  • Dissociation Binding Equilibria
  • EC50, IC50
  • Scatchard Plots
  • Medicinal Chemistry: Chapter 5

 

2/20
Competencies Lsn 10

Receptor Structure and Signal Transduction I

  • Ion Channels
  • G-Protein Coupled Receptors
  • Kinase-Linked Receptors
  • Intracellular Receptors 
  • Medicinal Chemistry: Chapter 6

 

2/22

Competencies Lsn 11

Receptor Structure & Signal Transduction II

  • Phosphorylation
  • GPCR Signal Transduction Pathways
  • Intracellular Receptors
  • Zinc Fingers
  • Handout

 

2/27

Test #1

 

 

3/1
Lsn 14

Thermodynamics of Ion Channels

  • Ion Concentration Gradients
  • Membrane Potentials
  • Inhibitory and Excitatory Changes

 

 

3/6

Electrochemistry & Thermodynamics I

 

 

3/8
PS5 Due

Electrochemistry & Thermodynamics II

 

 

3/20

Competencies Lsn 19

Cholinergics I

  • Cholinergic System
  • Acetylcholine: Structure, Receptor Binding
  • Medicinal Chemistry: Chapter 19

 

3/22
Competencies Lsn 20

Cholinergics II

  • Cholinergic Antagonists
  • Acetylcholinesterase Inhibitors
  • Medicinal Chemistry: Chapter 19

 

3/27
Competencies Lsn 21

Adrenergics I
  • Medicinal Chemistry: Chapter 20

 

3/29
Competencies Lsn 22

Adrenergics II
  • Medicinal Chemistry: Chapter 20

 

4/3
Competencies Lsn 23

Psychoactive Drugs I
  • Handout

 

4/5
Competencies Lsn 24

Psychoactive Drugs II
  • Handout

 

4/10
Competencies Lsn 25

Opium and Opioid Analgesics
  • Medicinal Chemistry: Chapter 21

 

4/12
Competencies Lsn 26

Chemistry of Local & General Anesthetics
  • Anesthetics and Opioid Analgesics Handout

 

4/17
Lsn 27

Test 2

 

 

4/19
Lsn 28

Review