Lsn 8: Receptors as Drug Targets I

• Know the molecular structures for these neurotransmitters:
• Cathecholamines: L-Dopa, dopamine, norepinephrine, and epinephrine
• Amino Acids: Glutamate, Aspartate, Glycine, GABA (gamma-aminobutyric acid)
• Understand how PCP (angel dust) and Memantine (Namenda) affect the glutamate receptor NMDA (N-Methyl-D-Aspartate)
• Understand the synthesis steps involved in the production of L-DOPA, dopamine, norepinephrine, and epinephrine
• Understand the role of glycine and GABA receptors
• Be able to explain the electrochemical basis for their inhibitory effects
• Clearly explain how each of the following substances affects the GABA-ergic system: ethanol, barbiturates, strychnine, diazepam (valium), and caffeine
• Explain the role of monoamine oxidase (MAO) for catecholamine neurotransmitters; identify the role of MAO inhibitors.
• Explain the effect of dopamine levels on brain activity
• Explain the effects of cocaine and of amphetamines on the dopaminergic system
• Outline the role of seratonin and identify the substance from which it is produced
• Explain what SSRI's are and what they are used for