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L1 T 8/23 |
Lecture 1. General Chemistry Review Electronegativity, Electron Configuration, Lewis Structures, Molecular Geometry, Hybridization, Double Bonds, Aromatic Structure, Kinetic Energy Molecular Distribution, and Vapor Pressure |
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L2
R 8/25 |
Lecture 2. Intermolecular Forces (Noncovalent Interactions) Ionic Interactions, Hydrogen Bonds, Van der Waals Interactions, Dipole-Dipole and Ion-Dipole Interactions, Repulsive Interactions, Water Solvation, and Hydrophobic Interactions Text Assignment: MedChem – 1.3 (Intermolecular Bonding Forces); Atkins – 5.1-5.5 (Intermolecular Forces) |
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L3 T 8/30 |
Lecture 3. Solubility and Lipids Thermodynamics of Liquid-Liquid Solubility, Octanol-Water Distribution Equilibrium Constants [Partition Coefficients (P)], Phospholipid Components and Structure, Cell Membrane Structure and Properties Text Assignment: Atkins – 8.9 (The Like-Dissolves-Like Rule); MedChem – 18.2.1 (Hydrophobicity), 1.2.1 (Cell Structure) Link: UCSF Membrane Tutorial (Great resource!!) Reading: The Components and Properties of Cell Membranes Link: Kimball's Biology Pages: Fats (Unsaturated Fats, Trans and Omega Fatty Acids, Phospholipids |
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L4 R 9/1 |
Lecture 4. Condensation and Hydrolysis Reactions Alcohols and Carboxylic Acids, Triglyceride Formation, Polyphosphate and Phospholipid Formation Handout: Condensation Reactions |
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L5 T 9/6 |
Lecture 5. Amino Acids Structure, Chirality, Side Chain Polarity, Peptide Bond,Peptide Condensation and Hydrolysis, Henderson-Hasselbalch Equation, Charge and pH, Solubility and pH Text Assignment: MedChem – Chapter 2 and Appendix 1 |
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L6 R 9/8 |
Lecture 6. Protein Structure Primary Structure, Disulfide Bonds, Secondary Structure - Alpha Helices and Beta Sheets, Tertiary/Quaternary Structures and Associated Noncovalent Interactions, Prions, PostTranslational Protein Modifications Text Assignment: MedChem – Chapter 2 |
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L7 T 9/13 |
Lecture 7. Enzymes: Structure and Function Enzyme Catalysis, Mechanism of Action, Active Site, Substrate Binding, Catalytic Roles, Michaelis-Menton Kinetics, Lineweaver-Burk Plots, Km and Vmax Determination, Turnover Numbers, Km and Substrate-Enzyme Affinity Text Assignment: MedChem – Chapter 3 (Enzymes: Structure and Function) Text Assignment: Kimball's Biology Pages: Enzymes Text Assignment: Kimball's Biology Pages: Enzyme Kinetics |
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L8 R 9/15 |
Lecture 8. Enzymes as Drug Targets Active Site Inhibitors, Allosteric Inhibition, Competitive / Uncompetitive / Non-Competitive Inhibitors, Suicidal Substrates Text Assignment: MedChem – Chapter 7 (Enzymes as Drug Targets) |
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L9 T 9/20 |
Lecture 9. Medical Approaches to Inflammation I Cyclooxygenase Case Study Reading: Protein Function – Section III Cyclooxygenase (COX): An Example of How Enzymes Function Reading: Molecular Basis of Inflammation |
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L10 R 9/22 |
Lecture 10. Medical Approaches to Inflammation II Steroids - Structure, Intracellular Receptors, Anti-Inflammatory MOA Reading: Molecular Basis of Inflammation Reading: Protein Function – Section II Nuclear Receptors: An Example of How Proteins Function Reading: Kimball's Biology Pages: Steroid Hormone Receptors and their Response Elements |
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L11 T 9/27 |
Lecture 11.
Receptors as Drug Targets I Neurotransmitters & Hormones, Agonists, Antagonists, Partial Agonists, Inverse Agonists, Treatment of Hormone-Dependent Breast Cancers Text Assignment: MedChem – Chapter 8, Sections 8.1-8.5 |
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L12 R 9/29 |
Lecture 12.
Receptors as Drug Targets II Desensitization & Sensitization; Tolerance & Dependence; Receptor Types & Subtypes; Affinity, Efficacy, & Potency; Ligand-Receptor Dissociation Equilibria, EC50, IC 50, Scatchard Plots Text Assignment: MedChem – Chapter 8, Sections 8.6-8.9 |
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L13 T 10/4 |
Lecture 13. Nucleic
Acids as Drug Targets Structure of DNA, Central Dogma, Intercalating Drugs, Alkylating & Metallating Agents, Cisplatin, 5-FU Text Assignment: MedChem – Chapter 6, Section 6.1 (Structure of DNA) Text Assignment: MedChem – Appendix 2 (The Standard Genetic Code) Text Assignment: MedChem – Chapter 9, Sections 9.1, 9.3 (Intercalating Drugs, Alkylating & Metallating Agents) Text Assignment: MedChem – Chapter 21, Section 21.2.3 (Alkylating & Metallating Agents) |
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L14 R 10/6 |
Lecture 14. Receptor Structure and Signal Transduction I – Overview of Ion Channel Receptors Ion Concentration Gradients, Ion Channel Structure and Mechanisms of Action, Ligand-Gated and Voltage-Gated Ion Channels, Cell Membrane Potentials, Nernst Equation and Membrane Equilibrium Potentials, Ion Movements and Resulting Inhibitory/Excitatory Potential Changes, Text Assignment: MedChem – Chapter 4, Section 4.6 (Ion Channel Receptors) Text Assignment: MedChem – Appendix 4 (The Action of Nerves) UCSF Reading: “Diffusion and Transport Across Membranes” Section on Ion Channels (pages 80-86) |
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T1 T 10/11 |
Mid-Term Examination on Material from Lectures 1-13 |
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L15 R 10/13 |
Lecture 15.
Receptor Structure and Signal Transduction II – Thermodynamics of Ion
Channels Sodium-Potassium-ATP Pump Mechanism, Cell Membrane Potentials, Nernst Equation and Membrane Equilibrium Potentials, Free Energy Changes of Ion Movement across Voltage and Concentration Gradients, Ion Movements and Resulting Inhibitory/Excitatory Potential Changes Text Assignment: MedChem – Chapter 4, Section 4.6 (Ion Channel Receptors), Appendix 4 (The Action of Nerves) UCSF Reading: “Diffusion and
Transport Across Membranes” Section on ATP-Driven Ion Pumps (pages 73-77) Wiki: 1. Resting Potential, 2. Na+/K+-ATPase |
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L16
R 10/20 |
Lecture 16.
Receptor Structure and Signal Transduction III – G-Protein Coupled Receptors
(GPCRs) G-Protein Coupled Receptor Structure, Evolutionary Tree of GPCRs, GPCR Signaling Mechanism of Action Text Assignment: MedChem – Section 4.7 (G-Protein Coupled Receptors) Text Assignment: MedChem – Section 5.1 (Signal Transduction Pathways for G-Protein Coupled Receptors) Text Assignment: MedChem – Section 5.2 (Signal Transduction Involving G-Proteins and Adenylate Cyclase) |
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L17
T 10/25 |
Lecture 17. Cholinergics I Nervous System, Cholinergic System, Acetylcholine Structure & Receptor Binding Text Assignment: MedChem – Chapter 19 and Appendix 4 (The action of nerves) |
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L18 R 10/27 |
Lecture 18. Cholinergics II Cholinergic Antagonists, Acetylcholinesterase Inhibitors Text Assignment: MedChem – Chapter 19 and Appendix 4 (The Action of Nerves) |
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L19 T 11/1 |
Lecture 19. Adrenergics Geometry of Adrenergic Receptors, Main Types of Norepinephrine Receptors, Interaction of Adrenergic Receptors with Neurotransmitters, MOA of Activated Receptors Text Assignment: MedChem – Chapter 20 |
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C1 R 11/3 |
Compensatory Time for Review Paper Preparation |
L20
T 11/8 |
Lecture 20. Psychoactive Drugs I: Stimulants and Tranquilizers Handout: |
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L21 R 11/10 |
Lecture 21. Psychoactive Drugs II: Anti-Depressants Handout: |
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L22 T 11/15 |
Lecture 22. Psychoactive Drugs III: Anti-Psychotics and Hallucinogens Handout |
L23 T 11/17 |
Lecture 23.
Psychoactive Drugs IV: Cannabinoids, Opium & Opioid Analgesics Cannabinoids, Source and History of Opiates, Structure of Opioids and Opioid Receptors, Endogenous Opioids, Side Effects of Opiates Text Assignment: MedChem – Chapter 21 |
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L24 T 11/22 |
Lecture 24.
Chemistry of Local & General Anesthetics MOA for Local Anesthetics, pKa Relevance, History of Cocaine Use by Humans, MOA for General Anesthetics, Molecular Structures of Widely Used General Anesthetics Handout: Local and General Anesthetics |
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T2 T 11/29 |
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R1 R 12/1 |
Review |