Lsn 1:  Intro to Drug Targets and Interactions I (Intermolecular Forces, Molecular Structure, Lewis Structures)

• Electronegativity, charge distribution, and molecular bonding structure
• Understand how to use relative electronegativities of atoms to clearly depict charge distribution across chemical bonds.  Be able to quickly predict partial charges on atoms within given molecules.
• Noncovalent interactions and intermolecular forces
• Understand and be able to clearly discuss and diagram the basis for attractions between molecules/ions to include ion hydration, hydrogen bonding, London dispersion, dipole-dipole, ion-dipole, and cation-p electron  interactions.
• Understand and use the relative magnitude (in kJ/mole) of chemical bonds (e.g. ionic, covalent and metallic) vs intermolecular forces (hydrogen bonding, London dispersion, dipole/dipole) interactions.
• Quickly draw diagrams that clearly show appropriate partial charges and intermolecular interactions among a given set of molecules or ions.
• Predict points of potential H-bond donors and acceptors for any given molecular structure.
• Predict and discuss relative boiling points (also vapor pressure, melting points, viscosity, surface tension) from molecular structure
• Molecular structure
• Draw molecular structures showing all bonds from a given molecular representation
• Quickly draw Lewis structures for a given molecule or ion
• Predict electron arrangement, molecular geometry, hybridization, and bond angles around given atoms in molecules
• Multiple bond structure
• Outline, discuss, and use aromatic electronic structure and geometry
• Know and discuss double/triple bond geometry and hybridization
• Outline and diagram cis/trans geometry about carbon-carbon double bonds
• Molecules: carboxylic acids, fatty acids, amino acids, and alkaloids
• Outline the structure of a carboxylic acid functional group and diagram its acid/conjugate base forms
• Be able to draw the structure for fatty acids, to include those having one or more points of unsaturation
• Distribution of molecular kinetic energies
• Calculate fractions of molecules having kinetic energies greater than a given energy at a given temperature
• Graphically represent and be able to clearly explain the distribution of kinetic energies of a collection of molecules at various temperatures
• Understand kinetic energy conversion into potential energy to separate molecules, to break bonds, or to react molecules