Date	Lesson
1/15	Gen Chem I Review: Electronegativity, Electron Configuration, Lewis Structures, Molecular Geometry, Hybridization, Double Bonds, Aromatic Structure, Kinetic Energy Molecular Distribution, and Vapor Pressure Text Assignment: GenChem - all applicable chapters; MedChem - Chapter 2
1/17 PS1 Due!	Gen Chem I Review - Intermolecular Forces (Noncovalent Interactions): Ionic Interactions, Hydrogen Bonds, Van der Waals Interactions, Dipole-Dipole and Ion-Dipole Interactions, Repulsive Interactions, Water Solvation, and Hydrophobic Interactions Text Assignment: GenChem - applicable chapters; MedChem - Chapter 2
1/22	Solubility: Thermodynamics of Liquid-Liquid Solubility, Octanol-Water Distribution Equilibrium Constants [Partition Coefficients (P)], Phospholipid Components and Structure, Cell Membrane Structure and Properties Text Assignment: MedChem – Chapter 2, also pp:273-275 (partition coefficient p) Link: UCSF Membrane Tutorial (Great resource!!)
1/24 PS2 Due!	Condensation and Hydrolysis Reactions: Alcohols and Carboxylic Acids, Triglyceride Formation, Polyphosphate and Phospholipid Formation Text Assignment: MedChem – Chapter 2 Handout: Condensation and Hydrolysis Reactions
1/29 PS3 Due!	Amino Acids: Structure, Chirality, Side Chain Polarity, Peptide Bond and Resonance, Peptide Condensation and Hydrolysis Text Assignment: MedChem – Chapter 3 and Appendix 1
1/31 PS4 Due!	Acid-Base Properties of Amino Acids: Henderson-Hasselbalch Equation, Charge and pH, Solubility and pH Text Assignment: GenChem - applicable chapters; MedChem - Chapter 3 UCSF Reading: “Diffusion and Transport Across Membranes” (Great resource!!)
2/5 PS5 Due!	Protein Structure: Primary Structure, Disulfide Bonds, Secondary Structure - Alpha Helices and Beta Sheets, Tertiary/Quaternary Structures and Associated Noncovalent Interactions, Prions, PostTranslational Protein Modifications Text Assignment: MedChem – Chapter 3
2/7	Chemical Kinetics: Factors Affecting Reaction Rates, Rate Law, Arrhenius Equation, Activation Energy, Kinetic Molecular Distribution Text Assignment: GenChem - applicable chapters
2/12 PS6 Due!	Enzyme Catalysis: Enzyme Catalysis Mechanism of Action, Active Site Substrate Binding, Enzyme Inhibition, Competitive and Allosteric Inhibitors Text Assignment: GenChem - applicable chapters, MedChem – Chapter 4
2/14	Enzyme Kinetics: Michaelis-Menton Kinetics, Lineweaver-Burk Plots, Km and Vmax Determination, Turnover Numbers, Km and Substrate-Enzyme Affinity Text Assignment: MedChem – Chapter 4
2/19	Mid-Term Exam: Some problems for practice…
2/21	Receptors as Drug Targets I: Neurotransmitters and Hormones, Ion Channel and Membrane receptors, Receptor-Ligand Interactions, Agonists and Antagonists, Sensitization, Tolerance, and Dependence Text Assignment: MedChem – Chapter 5
2/26 PS7 Due	Receptors as Drug Targets II: Affinity, Efficacy, and Potency; Dissociation Binding Equilibria, EC50, IC 50, and Scatchard Plots Text Assignment: MedChem – Chapter 5
2/28 PS8 Due	Receptor Structure and Signal Transduction I: Overview of Ion Channels, G-Protein Coupled Receptors, Kinase-Linked Receptors, Intracellular (Steroidal) Receptors Text Assignment: MedChem – Chapter 6
3/4	Ion Channels and Thermodynamics I: Ion Concentration Gradients, Cell Membrane Potentials, Nernst Equation and Membrane Equilibrium Potentials, Free Energy Changes of Ion Movement across Voltage and Concentration Gradients, Ion Movements and Resulting Inhibitory/Excitatory Potential Changes Text Assignment: MedChem – Chapter 6 UCSF Reading: “Diffusion and Transport Across Membranes” (pp73-77: ATP ion pumps, pp80-84: Ion channels)
3/6	Ion Channels and Thermodynamics II: Sodium-Potassium-ATP Pump Mechanism, Cell Membrane Potentials, Nernst Equation and Membrane Equilibrium Potentials, Free Energy Changes of Ion Movement across Voltage and Concentration Gradients, Ion Movements and Resulting Inhibitory/Excitatory Potential Changes Text Assignment: MedChem – Chapter 6 UCSF Reading: “Diffusion and Transport Across Membranes” (pp73-77: ATP ion pumps, pp80-84: Ion channels)
3/11 PS9 Due	Receptor Structure and Signal Transduction II: GPCR's: G-Protein Coupled Receptors Signaling Mechanism of Action Text Assignment: MedChem – Chapter 6
3/13	Receptor Structure and Signal Transduction III Steroids and Intracellular Steroidal Receptors: Steroid Structure and Hydrophobicity, Complex Ions and Zinc Fingers, Steroidal Receptors, Steroid-Receptor Mechanism of Action, Treatment of Hormone-Dependent Breast Cancers Text Assignment: MedChem – Chapter 6
3/25	Cholinergics I Nervous System, Cholinergic System, Acetylcholine Structure & Receptor Binding Text Assignment: MedChem – Chapter 19 and Appendix 4 (The action of nerves)
3/27	Cholinergics II Cholinergic Antagonists, Acetylcholinesterase Inhibitors Text Assignment: MedChem – Chapter 19 and Appendix 4 (The action of nerves)
4/1	Adrenergics Geometry of adrenergic receptors, main types of norepinephrine receptors, interaction of adrenergic receptors with neurotransmitters, MOA of activated receptors Text Assignment: MedChem – Chapter 20
4/3	Psychoactive Drugs I: Stimulants Handout:
4/8	Psychoactive Drugs II: Anti-Depressants Handout:
4/10	Psychoactive Drugs III: Hallucinogens Handout:
4/15	Opium and Opioid Analgesics Source and history of opiates, structure of opioids and opioid receptors, endogenous opioids, side effects of opiates Text Assignment: MedChem – Chapter 21
4/17	Chemistry of Local & General Anesthetics MOA for local anesthetics, pKa relevance, history of cocaine use by humans, MOA for general anesthetics, molecular structures of widely used general anesthetics Handout: Local and General Anesthetics
4/22	Test 2
4/24	Review
5/1	Final Cumulative Exam: Thursday, May 1 beginning at 11:30 AM