Chemistry 307: Bioorganic Chemistry

Dr. T. Christian Grattan/Dr. Jason Hurlbert (SIMS 301B)

Spring 2019 Winthrop University

MWF 12:30-1:20 PM (SIMS 113B)

Textbooks: Organic Chemistry with Biological Topics, 5^th ed., Smith REQUIRED

Course objectives: My goal for this course is to clearly explain the fundamental concepts of bioorganic chemistry and help to provide a bridge between organic and biochemistry. The students should be able to achieve a working understanding of the structure, function and reactivity for carbohydrates, lipids, proteins and nucleic acids. The students will also investigate the mechanisms of coenzymes and examine the basics of drug discovery.

Office Hours: Dr. Grattan: M 11:00 AM–12:00 PM; W 11:00–12:00 PM; R 10:00–11:00 PM; Dr. Hurlbert MWF 1:00 – 2:00 PM or by appointment (Grattan: 323-4927 or grattanc@winthrop.edu, Hurlbert: 323-4928 or hurlbertj@winthrop.edu)

We will also be accessible to answer questions on email. You will find that this course is different than any other courses you have taken in college. It is therefore important to stay on top of the material and get your questions answered as soon as possible. Please take advantage of our office hours or email to resolve these problems.

Attendance: Due to the unique nature of this course, each and every class meeting is important to better understand the material in the text. The students are responsible for all assignments for the course regardless of absence. 

Homework and Assignments: Problem set questions generated by Dr. Hurlbert and Dr. Grattan will also be assigned and graded which will be similar to those on the exams. You are strongly encouraged to work and study in groups!! Failure to turn in a problem set by the assigned time will result in a 5% penalty/day.

Grading System:

3 in-class Exams (100 points each)	300 points
Homework set average	100 points
Final Exam	200 points
Total	600 points

Grading Scale:

Percentage	Grade	Percentage	Grade
93-100%	A	77-79%	C+
90-93%	A-	70-76%	C
87-89%	B+	60-69%	D
80-86%	B	<60%	F

Exams: This course will consist of three one hour and fifteen minute in-class exams and one cumulative final exam given on the dates provided. Exam problems will be similar to the assigned problems. Each exam is limited to the allotted class time and the final exam will be limited to two and one-half hours. Make up exams will be given only with a valid excuse such as a severe personal or family crisis.

Exam 1	Monday, January 28	12:30 – 1:45 PM
Exam 2	Friday, February 22	12:30 – 1:45 PM
Exam 3	Friday, April 5	12:30 – 1:45 PM
Final Exam	Tuesday, April 30	11:30 – 2:00 PM

Cheating: Infractions of academic discipline are dealt with in accordance with the student Academic Misconduct Policy which is in the Student Conduct Code in the Student Handbook. Academic misconduct includes, but is not limited to,

providing or receiving assistance in a manner not authorized by the professor in the creation of work to be submitted for academic evaluation including papers, projects, and examinations; presenting, as one’s own, the ideas or words of

another for academic evaluation without proper acknowledgment; doing unauthorized academic work for which another person will receive credit or be evaluated; and presenting the same or substantially the same papers or projects

in two or more courses without the explicit permission of the professors involved. In addition, academic misconduct involves attempting to influence one’s academic evaluation by means other than academic achievement or merit.

S/U and Withdrawal Policy: According to University policy, Friday January 11, 2019 is the last day to drop this course. Wednesday, March 6, 2019 is the last day to withdraw from a spring semester course or to declare S/U for the course.

Students with Disabilities Policy: Winthrop University is committed to providing access to education.  If you have a condition which may adversely impact your ability to access academics and/or campus life, and you require specific accommodations to complete this course, contact the Office of Accessibility (OA) at 803-323-3290, or, accessibility@winthrop.edu. Please inform me as early as possible, once you have your official notice of accommodations from the Office of Accessibility.

Student code of conduct: As noted in the Student Code of Conduct: Responsibility for good conduct rests with students as adult individuals. Violations of the code of conduct found in the Student Conduct Code Academic Misconduct Policy will be dealt with as described in the policy.

Academic Success Center: Winthrop’s Academic Success Center is a free resource for all undergraduate students seeking to perform their best academically. The ASC offers a variety of personalized and structured resources that help students achieve academic excellence, such as tutoring, academic skill development (test taking strategies, time management counseling, and study techniques), group and individual study spaces, and academic coaching. The ASC is located on the first floor of Dinkins, Suite 106.  Please contact the ASC at 803-323-3929 or success@winthrop.edu. For more information on ASC services, please visit www.winthrop.edu/success.

Winthrop University’s Office of Nationally Competitive Awards (ONCA) identifies and assists highly motivated and talented students to apply for nationally and internationally competitive awards, scholarships, fellowships, and unique opportunities both at home and abroad. ONCA gathers and disseminates award information and deadlines across the campus community, and serves as a resource for students, faculty, and staff throughout the nationally competitive award nomination and application process. ONCA is located in Dinkins 222B. Please fill out an online information form at the bottom of the ONCA webpage www.winthrop.edu/onca and email onca@winthrop.edu for more information.

CHEM 307 Class Lecture/Exam Schedule

Date	Topic
7-Jan	Introduction, Carbohydrate structure
9-Jan	Redox reactions, Chain length reactions
11-Jan	Cyclization, Glycoside formation
14-Jan	Classification/Structure of Amino Acids, Acid-Base Behavior
16-Jan	Synthesis of Amino Acids/Peptides
18-Jan	Peptide Structure and Folding
21-Jan	MLK Jr Day – OFF
23-Jan	Sanger Method, Enzymatic Sequencing Methods
25-Jan	Computer Lab–Using Chimera to Visualize Protein Structure
28-Jan	Exam 1
30-Jan	Structure and Function of Lipids
1-Feb	Terpenes and Lipid Biosynthesis
4-Feb	Steroids and Synthesis
6-Feb	Biological Membranes
8-Feb	Membrane Transport
11-Feb	Nucleic Acids, Nucleosides and Nucleotides
13-Feb	PCR, Biosynthesis of DNA/RNA
15-Feb	Biosynthesis of Proteins, DNA Fingerprinting
18-Feb	Lab Synthesis of DNA Strands, DNA Based Drug Interaction
20-Feb	Review
22-Feb	Exam 2
25-Feb	Catalysis - Acid/Base/Nucleophilic
27-Feb	Catalysis - Metal Ion/Intermolecular/Intramolecular
1-Mar	Binding Sites
4-Mar	Enzyme Catalyzed Reactions
6-Mar	Enzyme Catalyzed Reactions
8-Mar	Enzyme Catalyzed Reactions
11-15-Mar	SPRING BREAK – OFF
18-Mar	Computer Lab-Active Site Investigations
20-Mar	Org Mech of Coenzymes - Cofactors/Vitamin B12, THF, TS
22-Mar	Vitamin K, H, B2, B1
25-Mar	Vitamin B3, PLP, Coenzyme A
27-Mar	Metabolic Pathways - ATP, Catabolism
29-Mar	Catabolism of Fats, Carbohydrates, Proteins
1-Apr	Citric Acid Cycle, Oxidative Phosphorylation, Anabolism
3-Apr	Review
5-Apr	Exam 3
8-Apr	Drug Discovery
10-Apr	Lead Modification, SAR
12-Apr	Increasing Oral Bioavailability
15-Apr	Genomics and Proteomics
17-Apr	Computer Lab - Inhibitors/Py Rx
19-Apr	Computer Lab - Inhibitors/Py Rx
22-Apr	Final Review
30-April	Final Exam (11:30 AM)