Chemistry 307: Bioorganic Chemistry
Dr.
T. Christian Grattan/Dr. Jason Hurlbert (SIMS 301B)
Spring
2019 Winthrop University
MWF
12:30-1:20 PM (SIMS 113B)
Textbooks: Organic Chemistry with Biological Topics, 5th
ed., Smith REQUIRED
Course objectives: My goal for this course is
to clearly explain the fundamental concepts of bioorganic chemistry and help to
provide a bridge between organic and biochemistry. The students should be able to achieve a
working understanding of the structure, function and reactivity for
carbohydrates, lipids, proteins and nucleic acids. The students will also
investigate the mechanisms of coenzymes and examine the basics of drug
discovery.
Office Hours: Dr. Grattan: M 11:00 AM–12:00
PM; W 11:00–12:00 PM; R 10:00–11:00 PM; Dr. Hurlbert MWF 1:00 – 2:00 PM or by
appointment (Grattan: 323-4927 or grattanc@winthrop.edu,
Hurlbert: 323-4928 or hurlbertj@winthrop.edu)
We will also be accessible to answer questions on email. You will find that this course is different
than any other courses you have taken in college. It is therefore important to stay on top of
the material and get your questions answered as soon as possible. Please take advantage of our office hours or
email to resolve these problems.
Attendance: Due to the unique nature
of this course, each and every class meeting is important to better understand
the material in the text. The students are responsible for all assignments for
the course regardless of absence.
Homework and Assignments: Problem set questions
generated by Dr. Hurlbert and Dr. Grattan will also be assigned and graded
which will be similar to those on the exams. You are strongly encouraged to
work and study in groups!! Failure to turn in a problem set by the assigned
time will result in a 5% penalty/day.
Grading System:
3 in-class Exams (100
points each) |
300 points |
Homework set average |
100 points |
Final Exam |
200 points |
Total |
600 points |
Grading Scale:
Percentage |
Grade |
Percentage |
Grade |
93-100% |
A |
77-79% |
C+ |
90-93% |
A- |
70-76% |
C |
87-89% |
B+ |
60-69% |
D |
80-86% |
B |
<60% |
F |
Exams: This course will consist
of three one hour and fifteen minute in-class exams and one cumulative final
exam given on the dates provided. Exam problems will be similar to the assigned
problems. Each exam is limited to the allotted class time and the final exam
will be limited to two and one-half hours. Make up exams will be given only with a valid excuse such as a severe personal or family crisis.
Exam 1 |
Monday, January 28 |
12:30 – 1:45 PM |
Exam 2 |
Friday, February 22 |
12:30 – 1:45 PM |
Exam 3 |
Friday, April 5 |
12:30 – 1:45 PM |
Final Exam |
Tuesday, April 30 |
11:30 – 2:00 PM |
Cheating: Infractions
of academic discipline are dealt with in accordance with the student Academic
Misconduct Policy which is in the Student Conduct Code in the Student Handbook.
Academic misconduct includes, but is not limited to,
providing or receiving
assistance in a manner not authorized by the professor in the creation of work
to be submitted for academic evaluation including papers, projects, and
examinations; presenting, as one’s own, the ideas or words of
another for academic
evaluation without proper acknowledgment; doing unauthorized academic work for
which another person will receive credit or be evaluated; and presenting the
same or substantially the same papers or projects
in two or more courses
without the explicit permission of the professors involved. In addition,
academic misconduct involves attempting to influence one’s academic evaluation
by means other than academic achievement or merit.
S/U and Withdrawal Policy: According
to University policy, Friday January 11, 2019 is the last day to drop this
course. Wednesday, March 6, 2019 is the last day to withdraw from a spring
semester course or to declare S/U for the course.
Students with Disabilities Policy: Winthrop University is committed to providing access to education. If you have a condition which may adversely impact your ability to access academics and/or campus life, and you require specific accommodations to complete this course, contact the Office of Accessibility (OA) at 803-323-3290, or, accessibility@winthrop.edu. Please inform me as early as possible, once you have your official notice of accommodations from the Office of Accessibility.
Student code of conduct: As noted in the Student Code of Conduct: Responsibility for good
conduct rests with students as adult individuals. Violations of the code of
conduct found in the Student Conduct Code Academic Misconduct Policy will be
dealt with as described in the policy.
Academic Success Center: Winthrop’s Academic Success Center is a free
resource for all undergraduate students seeking to perform their best
academically. The ASC offers a variety of personalized and structured
resources that help students achieve academic excellence, such as tutoring,
academic skill development (test taking strategies, time management counseling,
and study techniques), group and individual study spaces, and academic coaching.
The ASC is located on the first floor of Dinkins, Suite 106. Please
contact the ASC at 803-323-3929 or success@winthrop.edu. For more information on ASC services,
please visit www.winthrop.edu/success.
Winthrop University’s Office of Nationally Competitive Awards (ONCA) identifies and assists highly motivated and talented students to apply for nationally and internationally competitive awards, scholarships, fellowships, and unique opportunities both at home and abroad. ONCA gathers and disseminates award information and deadlines across the campus community, and serves as a resource for students, faculty, and staff throughout the nationally competitive award nomination and application process. ONCA is located in Dinkins 222B. Please fill out an online information form at the bottom of the ONCA webpage www.winthrop.edu/onca and email onca@winthrop.edu for more information.
CHEM 307 Class Lecture/Exam
Schedule
Date |
Topic |
7-Jan |
Introduction, Carbohydrate structure |
9-Jan |
Redox reactions, Chain length reactions |
11-Jan |
Cyclization, Glycoside formation |
14-Jan |
Classification/Structure of Amino Acids, Acid-Base
Behavior |
16-Jan |
Synthesis of Amino Acids/Peptides |
18-Jan |
Peptide Structure and Folding |
21-Jan |
MLK Jr Day – OFF
|
23-Jan |
Sanger Method, Enzymatic Sequencing Methods |
25-Jan |
Computer Lab–Using Chimera to Visualize Protein Structure |
28-Jan |
Exam
1 |
30-Jan |
Structure and Function of Lipids |
1-Feb |
Terpenes and Lipid Biosynthesis |
4-Feb |
Steroids and Synthesis |
6-Feb |
Biological Membranes |
8-Feb |
Membrane Transport |
11-Feb |
Nucleic Acids, Nucleosides and Nucleotides |
13-Feb |
PCR, Biosynthesis of DNA/RNA |
15-Feb |
Biosynthesis of Proteins, DNA Fingerprinting |
18-Feb |
Lab Synthesis of DNA Strands, DNA Based Drug Interaction |
20-Feb |
Review |
22-Feb |
Exam
2 |
25-Feb |
Catalysis - Acid/Base/Nucleophilic |
27-Feb |
Catalysis - Metal Ion/Intermolecular/Intramolecular |
1-Mar |
Binding Sites |
4-Mar |
Enzyme Catalyzed Reactions |
6-Mar |
Enzyme Catalyzed Reactions |
8-Mar |
Enzyme Catalyzed Reactions |
11-15-Mar |
SPRING BREAK – OFF |
18-Mar |
Computer Lab-Active Site Investigations |
20-Mar |
Org Mech of Coenzymes - Cofactors/Vitamin B12, THF, TS |
22-Mar |
Vitamin K, H, B2, B1 |
25-Mar |
Vitamin B3, PLP, Coenzyme A |
27-Mar |
Metabolic Pathways - ATP, Catabolism |
29-Mar |
Catabolism of Fats, Carbohydrates, Proteins |
1-Apr |
Citric Acid Cycle, Oxidative Phosphorylation, Anabolism |
3-Apr |
Review |
5-Apr |
Exam
3 |
8-Apr |
Drug Discovery |
10-Apr |
Lead Modification, SAR |
12-Apr |
Increasing Oral Bioavailability |
15-Apr |
Genomics and Proteomics |
17-Apr |
Computer Lab - Inhibitors/Py Rx |
19-Apr |
Computer Lab - Inhibitors/Py Rx |
22-Apr |
Final Review |
30-April |
Final Exam
(11:30 AM) |